Mutagenic impact of radiotherapy in B-cell lymphoma and multiple myeloma

For refinement of the single base substitution and indel profiles induced by genotoxic platinum and ionizing radiation, DHL4 cells were treated with cisplatin or radiotherapy. Single cells from doses corresponding to lethal and half-lethal (medium), were expanded into single-cell derived colonies and then subjected to 60x whole genome sequencing. 16 bam files were generated.

Type: Whole Genome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD50000001461	60X WGS of single cell-derived colonies of DHL4 cells treated with platinum or RT (or unexposed control). 16 bam files aligned using MGP1000 pipeline (GRCh38).	Illumina NovaSeq X	16