South African Blood Regulatory (SABR) Resource

Functional genomics resources are critical for interpreting human genetic studies, however they are predominantly from European-ancestry individuals. Here we present the South African Blood Regulatory (SABR) resource, a map of blood regulatory variation that includes three South Eastern Bantu-speaking groups. Using paired whole genome and blood transcriptome data from over 600 individuals, we map the genetic architecture of 40 blood cell traits derived from deconvolution analysis, as well as expression, splice, and cell type interaction quantitative trait loci (QTL).

Type: Transcriptome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001477	Phenotypic data, whole genome sequencing, blood RNA-seq, imputed variant calls, cell type estimates, gene expression levels, splicing measurements, and analysis covariates from South African Blood Regulatory (SABR) resource participants, which includes South Eastern Bantu-speaking groups.	Illumina NovaSeq 6000	754

Publications	Citations
A map of blood regulatory variation in South Africans enables GWAS interpretation. Castel SE, Tluway FD, Emde AK, Smyth N, Karim M, Sengupta D, Gray OA, Hendershott M, LeBaron von Baeyer S, Burke EE, Kaewert S, Nguyen KH, Choma SSR, Mashaba RG, Micklesfield LK, Kabudula C, Kahn K, Xavier Gomez-Olive F, Tollman S, Choudhury A, Mpangase PT, Hazelhurst S, Wasik KA, Yerges-Armstrong L, Ramsay M. Nat Genet 57: 2025 1628-1637	0

Publications

Citations

A map of blood regulatory variation in South Africans enables GWAS interpretation.
Castel SE, Tluway FD, Emde AK, Smyth N, Karim M, Sengupta D, Gray OA, Hendershott M, LeBaron von Baeyer S, Burke EE, Kaewert S, Nguyen KH, Choma SSR, Mashaba RG, Micklesfield LK, Kabudula C, Kahn K, Xavier Gomez-Olive F, Tollman S, Choudhury A, Mpangase PT, Hazelhurst S, Wasik KA, Yerges-Armstrong L, Ramsay M. Nat Genet 57: 2025 1628-1637