Excised DNA Circles from V(D)J Recombination Promote Relapsed Leukaemia

In this study, we show that ESCs replicate and persist through many cell generations. High ESC copies at diagnosis of BCP-ALL strongly correlate with subsequent relapse. These data provide the first demonstration that the V(D)J recombination by-product, when replicated to elevated levels, potently associates with the V(D)J recombinase to cause adverse disease outcomes.

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001518	This dataset includes: amplicon sequencing data for a total of 3 BCP-ALL patients - fastq files	Illumina MiSeq	5
EGAD50000001519	This dataset includes: whole exome sequencing data for a total of 23 BCP-ALL patients - BAM files	Illumina NovaSeq X	46

Publications	Citations
Excised DNA circles from V(D)J recombination promote relapsed leukaemia. Gao Z, Scott JNF, Edwards MP, Casey D, Wang X, Gillen AD, Ryan S, Russell LJ, Moorman AV, de Tute R, Cargo C, Ford AM, Westhead DR, Boyes J. Nature 645: 2025 774-783	1