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Defining Human Inner Ear Development: HIEDRA snRNAseq Atlas and Inner Ear Organoid Refinement

We present the Human Inner Ear Development snRNAseq Atlas (HIEDRA), a single-nucleus transcriptomic resource spanning fetal weeks 7–15. HIEDRA captures key events such as cochlear and vestibular sensory differentiation and secretory epithelium formation. It identifies novel markers distinguishing cochlear and vestibular lineages, implicates specific signalling pathways in secretory cell differentiation, and maps disorder-associated genes to vulnerable cell types. This dataset provides a foundation for modeling inner ear development and disorders, supporting regenerative and precision medicine.

Type: RNASeq
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001543	This dataset comprises single-nucleus RNA sequencing (snRNA-seq) data from nine human fetal inner ear samples, spanning developmental stages from fetal week 7 to week 15. Nuclei were isolated from dissected cochlear and vestibular tissues and processed using the 10x Genomics Chromium Next GEM Single Cell 3’ v3.1 platform. Libraries were prepared with oligo-dT priming to capture polyadenylated nuclear transcripts and sequenced using paired-end reads on an Illumina platform. The dataset enables the study of cochlear and vestibular differentiation, secretory epithelium development, and gene expression dynamics during inner ear maturation.	Illumina NovaSeq 6000	12