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Whole Exome sequencing of Baseline biopsies

Whole exome sequencing of BAseline CHC-noHCC and CHC-HCC biopsies.

Type: Exome Sequencing
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001591	We conducted a nested case–control study within a prospective liver biopsy biobank at the University Hospital Basel. Patients with chronic hepatitis C (CHC) who developed hepatocellular carcinoma (HCC) during follow-up (index cases, CHC-HCC) were identified and 1:2 propensity score-matched to CHC controls without HCC (controls, CHC-nonHCC). Matching included clinical, demographic, and virological risk factors for HCC. Liver biopsies were analyzed using RNA and whole-exome sequencing.	Illumina HiSeq 2500 Illumina NovaSeq 6000	139

Publications	Citations
Hepatitis C virus can induce gene expression changes associated with hepatocarcinogenesis. Boldanova T, Trulsson F, Ebrahimi F, Benjak A, Matter MS, Suslov A, Wieland S, Ng CKY, Heim MH. JHEP Rep 8: 2026 101897	0