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CLUSTER consortium RNAseq CD19 B cell dataset of UK JIA patients.

This study examines B cell transcriptomic profiles in Juvenile Idiopathic Arthritis (JIA) patients to investigate molecular mechanisms underlying disease heterogeneity. CD19+ B cells were isolated from peripheral blood samples and subjected to RNA sequencing to characterise gene expression patterns. The dataset includes patients with documented uveitis status to enable investigation of B cell contributions to the common JIA comorbidity.

Type: RNASeq
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001616	CLUSTER consortium RNA sequencing dataset from UK JIA patient cohort with documented uveitis status. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples and cryopreserved. Samples were subsequently thawed and flow-sorted for CD19+ B cells prior to RNA sequencing. Clinical metadata includes patient demographics and uveitis status at time of sampling.	Illumina NovaSeq 6000	133

Publications	Citations
Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis. Jebson BR, Ingledow B, Alexiou V, Kubiak J, Jenkins P, Meng Y, Kartawinata M, Restuadi R, Lin WY, Wallace C, Chu CJ, Solebo AL, Wedderburn LR, Rosser EC, CLUSTER consortium. Nat Commun 17: 2026 714	0