Whole Exome Sequencing of monomorphic epitheliotropic intestinal T-cell lymphoma and enteropathy associated T-cell lymphoma

Background : Enteropathy-associated T-cell lymphoma (EATL) and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) are aggressive malignancies with limited treatment options and poor prognosis. Our research on MEITL has uncovered its genetic portrait including hallmark SEDT2 mutations, expanded its pathological spectrum, and identified molecular biomarkers influencing patients’ outcome. In this study, we aimed to establish and clarify the similar and diverging features of EATL. Methods : A large combined cohort of patients with EATL (n=30) and MEITL (n=52) was assembled and tumor samples were used for whole-exome and RNA sequencing profiling.

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets

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Dataset ID	Description	Technology	Samples
EGAD50000001618	Six EATLs and three MEITLs (among which 5 had only tumoral tissue available) were sequenced using the xgen research panels v2.0 from IDT DNA (Newark, New Jersey, USA).	Illumina HiSeq 4000	15
EGAD50000001620	Fourteen MEITLs and one EATL previously had been sequenced using the SureSelectXT Target Enrichment System (Agilent Technologies, Santa Clara, CA, USA).	Illumina HiSeq 2500	30
EGAD50000001621	Twenty-six EATLs and 22 additional cases of MEITLs (among which 5 had only tumoral tissue available) were sequenced using the xgen research panels v1.0 and v2.0 from IDT DNA (Newark, New Jersey, USA).	Illumina HiSeq 4000	78