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Aging and viral evolution impair immunity against dominant pan-coronavirus-reactive T cell epitope

In this project we have analysed gene expression and Tcell repertoires of CD40L+41bb+ and CD40L-41bb- Tcells from young and old donors after stimulation with the iCope peptide.

Type: RNASeq
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001645	The data set contains the fastq files of the single cell RNAseq study associated with the iCope manuscript. There are fastq files for gene expression and for tcr enrichment for each sample.	Illumina NovaSeq 6000	34

Publications	Citations
Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope. Loyal L, Jürchott K, Reimer U, Meyer-Arndt L, Henze L, Mages N, Kostrzanowski J, Reus B, Mangold M, Kruse B, Dingeldey M, Sawitzki B, Michel J, Grossegesse M, Schnatbaum K, Wenschuh H, Nitsche A, Lachmann N, Timmermann B, Giesecke-Thiel C, Braun J, Kern F, Thiel A. Eur J Immunol 55: 2025 e51888	1
CD19 exon 2 skipping is a potential prognostic correlate of anti-CD19 CAR-T therapy relapse. Dam SH, Moranzoni G, Høie MH, Modvig S, Wadt KAW, Als-Nielsen B, Schmiegelow K, Vitting-Seerup K, Barnkob MB, Olsen LR. Front Mol Med 6: 2026 1763390	0