Genome- and epigenome-driven evolutionary dynamics of tumour-immune coevolution within primary colorectal cancers

This data includes targeting sequencing of the immunopeptidome from 94 samples, usually individual laser microdissected cancer glands, from 11 cases of colorectal cancer. The data were used to test for evidence of immunoediting (antigen depletion) in colorectal cancers. The full data description is provided in the original manuscript https://pmc.ncbi.nlm.nih.gov/articles/PMC10888923/. The 11 colorectal cancers had been previously multiomic profiled with data described in the parts of this disposition.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001650	Sequencing of laser-capture micro dissected colorectal tumour glands using a targeted capture panel. Tumours were previously subjected to WGS in the parent EPICC study. UMI-resolved aligned bam files, aligned to hg38.	Illumina NovaSeq 6000	94

Publications	Citations
Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy. Chun TW, Davey RT, Ostrowski M, Shawn Justement J, Engel D, Mullins JI, Fauci AS. Nat Med 6: 2000 757-761	307
Epigenetically driven and early immune evasion in colorectal cancer evolution. Lakatos E, Gunasri V, Zapata L, Househam J, Heide T, Trahearn N, Swinyard O, Cisneros L, Lynn C, Mossner M, Kimberley C, Spiteri I, Cresswell GD, Llibre-Palomar G, Mitchison M, Maley CC, Jansen M, Rodriguez-Justo M, Bridgewater J, Baker AM, Sottoriva A, Graham TA. Nat Genet 57: 2025 3039-3049	0