Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin

This study aimed to characterize immune cell states in nonlesional (NL) and perilesional (PL) skin of patients with vitiligo using single-cell RNA sequencing. Shared CD8⁺ T cell clusters were detected in both regions, with PL-derived cells enriched for immune activation pathways and NL skin showed stronger infiltration of regulatory T cells. These findings reveal functional T cell heterogeneity in vitiligo and highlight regulatory mechanisms that may limit depigmentation in NL skin.

Type: Transcriptome Analysis
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001874	scRNAseq dataset of vitligo dermis and epidermis for 6 patients. For each patient nonlesional and perilesional skin were sampled and processed separately.	Illumina NovaSeq 6000	12

Publications	Citations
Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin. Migayron L, Merhi R, Avril C, Léonard S, Zouine A, Jouenne F, Gilardeau S, Drullion C, Thiolat D, Mertinaj E, Humeau M, Mauroux A, Guégan JP, Gauthereau X, Mourah S, Darde T, Bordes S, Closs-Gonthier B, Seneschal J, Boniface K. Sci Adv 11: 2025 eadu9360	0