WES analysis of paired tumor and non-tumoral DNA of 4 patients with non-muscle-invasive bladder cancer

We performed WES of tumor DNA and non-tumoral DNA (extracted from PBMC) of 4 patients with non-muscle invasive bladder cancer, who after the tumor resection went on to receive BCG treatment as they had high-risk disease. In order to identify tumor-specific mutations that could give rise to patient-specific neo-epitopes, we performed paired WES of tumor and non-tumoral DNA for each patient. For patient UC2, 3 different tumors were resected at the same time and DNA from these 3 tumors were sent separately for WES.

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD50000002008	WES (FASTQ files) of paired tumor and PBMC samples of non-muscle-invasive bladder cancer patients. All CTRL samples originate from PBMC. For patient UC2, DNA from 3 different synchronous tumors were extracted. DNA from tumors was extracted from fresh frozen tumors,except for patient UC4 (FFPE). NB : patients aliases are the following :ROXY : UC1, OMAD : UC2, MAKI : UC3, HAPE : UC4	unspecified	10

Publications	Citations
Detection of spontaneous anti-neoepitope T-cell responses in non-metastatic bladder cancer patients. Brochier W, Nguyen S, Cesson V, Bricard O, van Baren N, Hames G, Dauguet N, Dano H, Tombal B, Rodrigues-Dias SC, Masnada A, Genolet R, Harari A, Roth B, Lucca I, Nardelli-Haefliger D, Coulie PG, Derré L. Front Immunol 16: 2025 1627914	0