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Transcriptomic profiling of Hedgehog-high and Hedgehog-low HPV-negative HNSCC

This study investigates transcriptomic differences between Hedgehog-high and Hedgehog-low HPV-negative head and neck squamous cell carcinoma (HNSCC). Tumors were stratified based on pathway-level genomic alteration scores and imaging-associated Hedgehog activity. RNA sequencing was performed on archival FFPE tumor samples to assess pathway activation and transcriptional programs associated with Hedgehog signaling. The dataset supports integrative radiogenomic and functional analyses of tumor-intrinsic signaling pathways.

Type: RNASeq
Archiver: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002225	This dataset comprises RNA-seq data from 12 high-quality archival FFPE HPV-negative HNSCC tumor samples, selected for downstream differential expression analysis. Data include raw and processed RNA-seq files generated using short-read 3' sequencing optimized for FFPE material. The dataset was used to evaluate Hedgehog pathway activation and related transcriptional signatures. Sequencing was performed on bulk tumor tissue.	NextSeq 2000	12