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Single-nucleus profiling of severe alcohol-related hepatitis

Single-nucleus profiling of severe alcohol-related hepatitis reveals immune and parenchymal states behind corticosteroid response. Single-nucleus RNA sequencing was performed on liver biopsies from patients with biopsy-proven sAH (n=17), including paired baseline and day 8 biopsies in a subset (n=8). Patients were classified as corticosteroid responders (sAH-R; Lille score <0.45) or non-responders (sAH-NR; Lille score ≥0.45). Liver biopsies from patients with acute decompensation of alcohol-related liver disease (AD; n=5) and healthy controls (n=4) were included for comparison.

Type: Transcriptome Sequencing
Archive: European Genome-phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD50000002317	Single-nucleus RNA sequencing was performed on liver biopsies from patients with biopsy-proven sAH (n=17), including paired baseline and day 8 biopsies. Libraries were prepared with 10X Genomics kits and sequenced on an Illumina NovaSeq6000.	Illumina NovaSeq 6000	34