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snRNA-seq schizophrenia control Prefrontal cortex

In this study, we performed RNA sequencing of single nuclei from the prefrontal cortex of donors with and without schizophrenia using the 10x Genomics Chromium Single Cell protocol. The project rationale is to determine cell type specific transcriptomic changes between the two groups and linking them to the risk for schizophrenia.

Type: Transcriptome Sequencing
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002447	Human Brodmann Area 8/9 tissue from 43 schizophrenia subjects and 42 control individuals was obtained from three sources, NBB (Netherlands Brain Bank), Craig A. Stockmeier (University of Mississippi Medical Center), Macedonian/New York State Psychiatric Institute Brain Collection (Andrew J. Dwork, Columbia University). All subjects included in the study were matched between the two groups for age, gender, and postmortem interval. Nuclei were isolated and enriched for 85% neuronal nuclei before single nucleus RNA sequencing was performed with 10x Genomics Chromium Single Cell protocol v3.	Illumina NovaSeq X	85

Publications	Citations
Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia. Bast L, Yao S, Martínez-López JA, Memic F, French H, Valiukonyte M, Karlsson R, Wen J, Song J, Zhang R, Abrantes A, Koopmans F, Österholm AM, Rosoklija G, Mann JJ, Stankov A, Trencevska I, Dwork A, Stockmeier CA, Love MI, Giusti-Rodriguez P, Smit AB, Sullivan PF, Hjerling-Leffler J. medRxiv None: 2025 2025.03.14.25323827	2

Publications

Citations

Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia.
Bast L, Yao S, Martínez-López JA, Memic F, French H, Valiukonyte M, Karlsson R, Wen J, Song J, Zhang R, Abrantes A, Koopmans F, Österholm AM, Rosoklija G, Mann JJ, Stankov A, Trencevska I, Dwork A, Stockmeier CA, Love MI, Giusti-Rodriguez P, Smit AB, Sullivan PF, Hjerling-Leffler J. medRxiv None: 2025 2025.03.14.25323827