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Circulating mRNA and miRNA signatures predicting response to lifestyle intervention in pediatric obesity

This study aims to identify circulating transcriptomic biomarkers predictive of response to lifestyle intervention in pediatric obesity. Peripheral blood whole-transcriptome RNA sequencing and microRNA sequencing were performed in a subset of children and adolescents with obesity participating in a prospective 12-month multicenter lifestyle modification program. The generated data are linked to detailed demographic, clinical, anthropometric, biochemical, and treatment outcome variables. These resources support investigations of molecular pathways underlying obesity, treatment responsiveness, and precision medicine approaches in pediatric obesity management.

Type: Transcriptome Sequencing
Archiver: Federated EGA Poland

2 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002757	This dataset contains whole-transcriptome RNA sequencing data generated from peripheral blood samples collected from children and adolescents with obesity participating in a 12-month multicenter lifestyle intervention study. Libraries were prepared using the Illumina Stranded Total RNA Prep with Ribo-Zero Plus protocol and sequenced on the Illumina NextSeq platform using paired-end 2 × 150 bp sequencing. The dataset includes fastq files and associated metadata for transcriptomic analyses aimed at identifying biomarkers predictive of response to lifestyle modification.	NextSeq 500	50
EGAD50000002758	This dataset contains small RNA sequencing data generated from peripheral blood samples collected from children and adolescents with obesity enrolled in a 12-month multicenter lifestyle intervention study. Libraries were prepared using the QIAseq miRNA Library Kit and sequenced on the Illumina NextSeq platform using single-end 75 bp sequencing. The dataset includes fastq files and associated metadata for the identification of circulating microRNA biomarkers associated with response to lifestyle modification and obesity-related metabolic traits.	NextSeq 500	48