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Data has been deposited at the European Genome-phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS50000001929. Further information about EGA can be found at https://ega-archive.org and The European Genome-phenome Archive in 2021: 10.1093/nar/gkab1059

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Epigenetic and Transcriptomic profiling of hiPSC- and UCB-HSC derived CD4+CD8+ T progenitors

Generation of T cell subsets from human induced pluripotent stem cells (hiPSCs) in defined in vitro systems could provide a valuable model to study the mechanisms of human T cell development in the thymus and serve as a scalable source for therapeutic cell products. We generated a unique DNA methylation (DNAmeth) and RNA-seq dataset of in vitro generated hiPSC-derived and umbilical cord blood (UCB-) derived T cell progenitor subsets from a feeder-free differentiaion system and integrated them with data from primary human thymocyte populations.

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Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD50000002799 NextSeq 2000 14