CSF PBAT methylome profiling in multiple sclerosis - shallow seq

This study contains shallow-depth post-bisulfite adaptor tagging (PBAT) whole-genome bisulfite sequencing data generated from cerebrospinal fluid (CSF) cells from individuals with relapsing-remitting multiple sclerosis and neurological disease controls. The shallow-sequencing dataset includes lower-depth technical replicate sequencing of discovery-cohort samples and an independent validation cohort. These data were generated to assess the reproducibility of candidate MS-associated DNA methylation differences identified by deep PBAT-seq and to support validation of methylation signatures in CSF immune cells. The study contributes to the characterization of immune regulatory, adhesion, migration and protocadherin-associated epigenetic changes in multiple sclerosis.

• Type: Epigenetics
• Archive: European Genome-phenome Archive (EGA)