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Tumoral immune microenvironment profiling in B-cell non-Hodgkin lymphoma stratifies patients in different prognostic groups

Non-Hodgkin lymphomas (NHL) are heterogeneous B-cell malignancies in which the tumor immune microenvironment (TIM) influences disease progression and has emerging potential for prognostic patient stratification. This project investigates the TIM of NHL by combining multiparameter flow cytometry with targeted DNA sequencing of NHL biopsies. The study aimed to characterize the immune cell composition, immune checkpoint expression, and mutational landscape, and to evaluate their association with clinical and prognostic features across NHL subtypes. The classification of TIM profiles by flow cytometry predicts clinical outcomes in patients with follicular lymphoma (FL), highlighting its potential value for risk stratification and the identification of novel immunotherapeutic targets in NHL.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002845	Targeted DNA sequencing was performed on 60 non-Hodgkin lymphoma (NHL) samples using a custom next-generation sequencing panel targeting the coding regions of 190 genes recurrently mutated in hematological malignancies. Libraries were sequenced on an Illumina NovaSeq 6000 platform using 2 × 150 bp paired-end reads. The dataset includes the raw sequencing data (FASTQ files) for all 60 samples.	Illumina NovaSeq 6000	60