Copied to clipboard!

Fibrinoid-associated neutrophils promote human placentation

This study investigates how neutrophils are locally adapted at the early human maternal-fetal interface and how they contribute to invasive placentation. Using 10x Genomics Chromium Flex single-cell RNA sequencing of first-trimester decidua basalis, together with cytometry, spatial imaging, and functional co-culture assays, we identified decidual fibrinoid-associated neutrophils (dFANs) within the fibrinoid Rohr’s layer. These cells display a compartment-associated phenotype and secrete MMP-9, which promotes extravillous trophoblast motility and contributes to activation of latent TGF-β. The goal of the project was to define the function of neutrophil reprogramming in early pregnancy and its role in supporting human trophoblast invasion.

Type: RNASeq
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002868	This study investigates how neutrophils are locally adapted at the early human maternal-fetal interface and how they contribute to invasive placentation. Using 10x Genomics Chromium Flex single-cell RNA sequencing of first-trimester decidua basalis, together with cytometry, spatial imaging, and functional co-culture assays, we identified decidual fibrinoid-associated neutrophils (dFANs) within the fibrinoid Rohr’s layer. These cells display a compartment-associated phenotype and secrete MMP-9, which promotes extravillous trophoblast motility and contributes to activation of latent TGF-β. The goal of the project was to define the function of neutrophil reprogramming in early pregnancy and its role in supporting human trophoblast invasion.	NextSeq 2000	4