Genomic signatures of recent human adaptation to the Foraging-to-Farming Transition

Human populations across multiple regions transitioned from hunting and foraging to sedentary farming societies starting ~10 to 12kya, narrowing dietary diversity and transforming relationships with animals and pathogens. To investigate how these ecological changes shaped human adaptations, we analyzed high-coverage whole-genome sequence data from 1,092 individuals practicing hunter-gatherer, agriculturalist, and pastoralist lifestyles across eight geographic regions spanning Africa, Asia, and Oceania. Collectively, our findings illuminate the genetic legacy of ecological changes associated with the foraging-to-farming transition and highlight the central role of non-coding regulatory variation in human adaptation.

• Type: Whole Genome Sequencing
• Archive: European Genome-phenome Archive (EGA)