Copied to clipboard!

Whole Exome Sequencing

ASTEROID Phase 1 trial of combination IAP inhibitor ASTX660 and pembrolizumab. Matched tumour biopsies and PBMCs were sequenced.

Type: Exome Sequencing
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002936	WES data from ASTEROID patient tumour (labeled A, n=14) and PBMC (labeled B, n=18) samples; total n=32; Fastq files	Illumina NovaSeq X Plus	32

Publications	Citations
IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial. Tiu C, Yau W, Tenev T, Lionarons D, Leung C, Sanchez-Perez V, Codacci-Pisanelli G, Lai X, Zachariou A, Hussain A, Prout T, Parmar M, Baikady B, Goicoechea M, Layzell S, Guppy N, Roxanis I, Lund T, Dos Reis DC, Almeida CP, Silveira TL, Ferreira A, Gurel B, Bertan C, Crespo M, Flohr P, Baker AM, Graham T, Zapata L, Salas C, Mandal S, Dunlop A, Sims M, Ward G, Smyth T, Jueliger S, Davis M, Potapov I, Oganesian A, Chan D, Leino M, Basu S, Samson A, Murphy JM, Tunariu N, Johnston EW, Ring A, Turner N, Tutt ANJ, Swain A, Minchom A, Sharp A, Paschalis A, Banerji U, de Bono J, Basu B, Yap C, Haider S, Lopez J, Meier P. Nat Commun 17: 2026 11255	0

Publications

Citations

IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial.
Tiu C, Yau W, Tenev T, Lionarons D, Leung C, Sanchez-Perez V, Codacci-Pisanelli G, Lai X, Zachariou A, Hussain A, Prout T, Parmar M, Baikady B, Goicoechea M, Layzell S, Guppy N, Roxanis I, Lund T, Dos Reis DC, Almeida CP, Silveira TL, Ferreira A, Gurel B, Bertan C, Crespo M, Flohr P, Baker AM, Graham T, Zapata L, Salas C, Mandal S, Dunlop A, Sims M, Ward G, Smyth T, Jueliger S, Davis M, Potapov I, Oganesian A, Chan D, Leino M, Basu S, Samson A, Murphy JM, Tunariu N, Johnston EW, Ring A, Turner N, Tutt ANJ, Swain A, Minchom A, Sharp A, Paschalis A, Banerji U, de Bono J, Basu B, Yap C, Haider S, Lopez J, Meier P. Nat Commun 17: 2026 11255