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Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytomas and oligodendrogliomas

The life expectancy of patients with diffuse IDH-mutant low-grade gliomas (IDHmt LGG) ranges from 5 to over 20 years. Tumor behavior, including spontaneous growth rate, varies even within homogeneously classified subtypes of oligodendroglioma and astrocytoma. Risk-adjusted treatment strategies are needed to avoid therapy-related toxicities without compromising outcome. The spontaneous tumor volume growth rate (TVGR) serves as a prognostic marker and predicts response to therapy. Accurate prediction of TVGR through biomarkers would enable improved evidence-based risk management.

Type: RNASeq
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002974	RNA data was extracted from 96 frozen tumor tissue (IDH-mutant low-grade gliomas). The fastq files come from sequencing performed on an Illumina NovaSeq 6000 S2 v1.5 flow cell for 100 cycles of single read. Sequencing data were demultiplexed using the bcl2fastq2 Conversion Software (version 2.20, Illumina).	Illumina NovaSeq 6000	96

Publications	Citations
Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytomas and oligodendrogliomas. Darlix A, Bady P, Deverdun J, Bars EL, Coget A, Meriadec J, Carrière M, Duffau H, Hegi ME. Neuro Oncol 28: 2026 911-922	1