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Essential tremor blood transcriptional variation and its association with clinical and neuroimaging phenotypes

We performed whole-blood RNA-sequencing, brain MRI and clinical assessments for a cohort of essential tremor patients and controls. Both groups were cognitively unimpaired. The ET group had substantial motor and functional impairment with a mean disease duration of 7.8 years. In this project, we aimed to compare essential tremor and control groups on whole blood transcriptomic data, and within the essential tremor group, to test the correlation of transcriptional variation with key clinical and neuroimaging phenotyes.

Type: Transcriptome Analysis
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003060	This dataset contains controlled-access raw paired-end whole-blood RNA sequencing data from individuals with essential tremor and healthy controls. RNA libraries were generated using poly-A enrichment and strand-specific mRNA library preparation and sequenced as 2 × 150 bp paired-end reads on the NovaSeq X Plus platform. The study investigated peripheral transcriptional variation associated with essential tremor and with clinical, cognitive, and structural neuroimaging phenotypes.	Illumina NovaSeq X Plus	64