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Multiomic Analysis of Treatment Naive MYD88 Mutated Patients with Waldenstrom’s Macroglobulinemia

This study consists of RNASeq with additional whole exome sequencing and enhanced reduced representational bisulfite sequencing for a subset of study participants. Samples were derived from CD19 selected bone marrow biopsies. Deidentified clinical annotation of these samples is also included. Samples range from patients at the earliest stages of disease development to those who are about to initiate therapy. The aim of this study is to look for clinical/molecular subtypes of WM and study the biology of disease evolution/progression.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003127	This dataset includes 111 RNASeq samples, 88 tumor/germline paired whole exomes and 35 enhanced reduced representational bisulfite sequencing samples. All studies associated with a given patient were collected from the same biopsy. 14 healthy donor B-cell and 13 healthy donor memory B-cell controls are available for the for RNAseq data. 8 bone marrow CD138+ healthy donor plasma cells, 6 healthy donor B-cells, 6 memory B-cells, and 5 IgM multiple meyloma samples are included in the bisulfite sequencing data.	Illumina HiSeq 2000 Illumina HiSeq 2500 NextSeq 550	165