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Spatial Profiling Uncovers a High-Risk Stromal-Fibrotic Subtype in Hormone Receptor-Positive, HER2-Negative Breast Cancer

This study characterizes the spatial transcriptomic landscape of treatment-naive hormone receptor-positive, HER2-negative invasive breast carcinomas of no special type. Spatial transcriptomic profiling was performed on 86 tumors from 85 patients and integrated with histopathological annotation and cell-type deconvolution. The analyses were used to identify spatially defined molecular and microenvironmental patterns and to derive the Spatial4HR+ subtypes. These subtypes were subsequently evaluated for biological characteristics and clinical outcome associations.

Type: Transcriptome Sequencing
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003198	This dataset contains raw sequencing data from spatial transcriptomic profiling of 86 treatment-naive primary hormone receptor-positive, HER2-negative breast tumors from 85 patients. Libraries were generated using the 10x Genomics Visium Spatial Gene Expression workflow and sequenced on an Illumina NovaSeq 6000. The dataset comprises the FASTQ files associated with the spatial transcriptomic experiments included in this study.	Illumina NovaSeq 6000	87