Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

Previous investigations of clonal hematopoiesis (CH) have analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here we performed targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived DNA, in 11,234 individuals enrolled in Biobank Japan cohort to delineate the landscape of CH-related SNVs/indels and CNAs.

• Type: Population
• Archiver: Japanese Genotype-phenotype Archive (JGA)