NIH Genome-Wide Association Studies of Amyotrophic Lateral Sclerosis

Study ID Alternative Stable ID Type
phs000101 Case-Control

Study Description

The cause of sporadic amyotrophic lateral sclerosis (ALS) is unknown. To identify the genetic factors underlying this fatal neurodegenerative disease, we performed a series of genome-wide association studies of ALS. These studies are divided into three distinct stages, each associated with a separate data release. A description of each stage is provided below.

In the first stage, we genotyped 555,352 SNPs in 276 US cases diagnosed with ALS and 271 US controls. These samples were obtained from the National Institute of Neurological Disorders and Stroke (NINDS) DNA Repository at Coriell. The 276 US cases were genotyped on Illumina HumanHap550v1.1 SNP arrays, whereas the 271 US controls were genotyped on both Illumina HumanHap250Sv1.0 and Illumina HumanHap300v1.1 SNP arrays. The genotype data was released in June 2008 under the accession number phs000101.v1.p1 and was associated with the following publication: Schymick JC et al. (2007) Genome-wide ... (Show More)

Archive Link Archive Accession
dbGaP phs000101

Who archives the data?

There are no publications available