Genetic Studies in the Hutterites

Study ID Alternative Stable ID Type
phs000185 Population

Study Description

We conducted genome wide association studies (GWAS) of disease-associated quantitative phenotypes in the Hutterites, a founder population of European descent. The Hutterites in our studies live on communal farms in South Dakota and are related to each other through multiple lines of descent in a 3,657-person, 13-generation pedigree with 64 founders. The small number of founding genomes reduces genetic heterogeneity whereas their communal lifestyle ensures that non-genetic factors are remarkably uniform between individuals. During our Phase 1 studies, between 1996 and 1997, we measured qualitative and quantitative phenotypes that are associated with common diseases in ~750 individuals living in 9 Hutterite colonies. These individuals were genotyped using the Affymetrix 500k array. The SNPs included in our GWAS had >90% call rates, minor allele frequencies >5%, Hardy-Weinberg p-values >0.001 (corrected for Hutterite population structure), and fewer than 5 Mendelian errors. During our Phase 2 studies, between 2006 and 2009, we phenotyped ~900 individuals living in 9 ... (Show More)

Archive Link Archive Accession
dbGaP phs000185

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