VitGene Generalized Vitiligo Genetics Study

Study ID Alternative Stable ID Type
phs000224 Case-Control

Study Description

Generalized vitiligo is an autoimmune disease in which melanocyte loss results in patchy depigmentation of skin and hair. For this GWAS of generalized vitiligo, 579,146 SNPs were genotyped in 1514 generalized vitiligo cases of European-derived white (CEU) ancestry versus data from 2813 "public" CEU controls. 49 strongly associated SNPs from the first phase of the GWAS were then tested in two replication studies, one comparing 677 independent cases and 1106 CEU controls, and the other a family-based analysis of 204 CEU simplex generalized vitiligo trios and 310 CEU multiplex families. Overall, significant association of generalized vitiligo was detected for SNPs in several genes previously associated with other autoimmune diseases, including MHC class I (P = 9.05 x 10-23) and class II (P = 4.50 x 10-34) loci, PTPN22 (P = 1.31 x 10-7), LPP (P = 1.01 x 10-11), IL2RA (P = 2.78 x 10-9), UBASH3A (P = 1.26 x 10-9), and C1QTNF6 (P = 2.21 x 10-16). Association was also detected for SNPs in two novel ... (Show More)

Archive Link Archive Accession
dbGaP phs000224

Who archives the data?

There are no publications available