Genome-Wide Association Study of Preterm Birth

Study ID Alternative Stable ID Type
phs000332 Case-Control

Study Description

Preterm birth (PTB, born before 37 weeks of gestation) accounts for 12.5% of all births in the U.S. It is a leading cause of neonatal mortality and post-natal morbidity. The highest rate of PTB occurs among the black population (17.8%). Available literature and our research findings strongly suggest that genetic factors play an important role in PTB. Supported by a grant from the NICHD, the goal of this project is to conduct a genome-wide association (GWA) study and apply advanced statistical methods to identify susceptibility loci of PTB. We will genotype 1,000 black mothers who delivered preterm births (cases) and 1,000 age-matched black mothers who delivered term births (controls) at the Boston Medical Center (BMC), using the Illumina HumanOmni 2.5 array. Subsequently, we will perform replication analysis of the SNPs using independent, multi-ethnic samples from the BMC. We also will genotype the significant single-nucleotide polymorphisms (SNPs) in babies born to the study mothers, and examine if the fetal gene interacts with the maternal gene to affect the risk of PTB.

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Archive Link Archive Accession
dbGaP phs000332

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