Gene fusion discovery through RNA sequencing of nine human glioblastoma stem cell lines

Study ID Alternative Stable ID Type
phs000505 RNA Sequencing

Study Description

We used massively parallel, paired-end sequencing of expressed transcripts (RNA-seq) to detect novel gene fusions in short-term cultures of glioma stem-like cells freshly isolated from nine patients carrying primary glioblastoma multiforme (GBM). The culture of primary GBM tumors under serum-free conditions selects cells that retain phenotypes and genotypes closely mirroring primary tumor profiles as compared to serum-cultured glioma cell lines that have largely lost their developmental identities.

Archive Link Archive Accession
dbGaP phs000505

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