Study

Whole Exome Sequencing for Familial Intracranial Aneurysm (FIA I-II) Study

Study ID Alternative Stable ID Type
phs000636 Family

Study Description

The goal of this study is to identify the genes underlying the risk of intracranial aneurysm (IA). The FIA Study initially recruited families appropriate for linkage analysis. Therefore, the recruitment focus was not only on probands with a family history of IA but also required that biological samples be obtained for at least two affected family members. Family members underwent detailed interviews for medical, social and family history, and provided blood samples for DNA extraction. Over 400 multiplex IA families were recruited and enrolled.

The whole exome sequencing project aims to identify novel and rare (in the general population) genetic variants that are enriched in seven extended multiplex families with a strong familial aggregation of intracranial aneurysms.

Archive Link Archive Accession
dbGaP phs000636

Who archives the data?

There are no publications available