Genetic measurement of memory B-cell recall using antibody repertoire sequencing

Study ID Alternative Stable ID Type
phs000656 Longitudinal

Study Description

We developed an improved high throughput sequencing approach to measure the quantities and sequences of the repertoire of antibody heavy chain RNA in a blood sample. Using this approach we analyzed the antibody repertoire in response to yearly vaccinations with influenza vaccines TIV and LAIV in healthy adults in two subsequent years. We determined vaccine response patterns specific to LAIV and TIV and found antibody sequences that were shared between two samples of the same individuals following influenza vaccination in subsequent years, thereby providing a genetic measurement of B-cell memory recall.

Archive Link Archive Accession
dbGaP phs000656

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