NICHD Genomic and Proteomic Network for Preterm Birth Research (GPN)

Study ID Alternative Stable ID Type
phs000714 Case-Control

Study Description

We performed genome-wide association studies (GWAS) to study the Spontaneous Preterm birth (SPTB).

Maternal and neonatal DNA from 743 SPTB (20 to and less than 34 weeks), and 752 controls (39 to and less than 42 weeks) who fully consented for public research usage were collected from participants in several clinical centers in Alabama, Illinois, New York, North Carolina, Rhode Island, Texas, and Utah. Cases were 1:1-matched with controls according to race/ethnicity (White, Hispanics, African Americans, and Others), maternal age (<20, 20-29, 30-39, 40+), and parity (yes or no). To determine the case-control status for each participant, a Gestational Age (GA) was determined.

DNA samples were taken from blood or saliva if blood was not available. Automated DNA extractions were performed on the Qiagen M48 robot, and samples were organized in 96-well plates with barcoding and sample tracking systems. Subsequent manipulations were performed on the Biomek FX liquid handling workstation with 96-channel pipetting. DNA quantitation was performed by dye-based assay on a ... (Show More)

Archive Link Archive Accession
dbGaP phs000714

Who archives the data?

There are no publications available