Study

Oncogenomics of Malignant Peripheral Nerve Sheath Tumors

Study ID Alternative Stable ID Type
phs000792 Case Set

Study Description

Malignant peripheral nerve sheath tumors (MPNSTs) are a group of highly aggressive soft tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1-associated), or after radiotherapy (RT-associated). We utilized comprehensive genomic approaches and identified recurrent loss-of-function somatic alterations in the Polycomb repressive complex 2 (PRC2) core components EED or SUZ12. Genetic loss of either of these two genes results in complete loss of H3K27me3 and aberrant transcriptional programming in the affected tumors.

Archive Link Archive Accession
dbGaP phs000792

Who archives the data?

There are no publications available