DNA Methylation age and mortality in the Lothian Birth Cohorts of 1921 and 1936

Study ID Alternative Stable ID Type
phs000821 Longitudinal Cohort

Study Description

The study examined the association between DNA methylation age and mortality. Methylation age was estimated in 4 cohorts (including the Lothian Birth Cohorts of 1921 and 1936) and related to subsequent time-to-death. Across all four cohorts there was a strong correlation between predicted methylation age and chronological age. For individuals with a 5 year age acceleration (DNA methylation age - chronological age = 5), there was a meta analysed hazard ratio of mortality of 1.21 [1.14, 1.29]. Phenotype data associated with the study are available through dbGaP, the methylation raw data are available through the European Genome-phenome Archive (EGA; accession number EGAS00001000910).

Archive Link Archive Accession
dbGaP phs000821

Who archives the data?

There are no publications available