Study

National Institute of Neurological Disorders and Stroke (NINDS), Family Study of Essential Tremor (FASET), Identification of Susceptibility Genes for Essential Tremor

Study ID Alternative Stable ID Type
phs000966 Multiplex Families

Study Description

The Familial Study of Essential Tremor (FASET) was designed to identify susceptibility genes for Essential Tremor. ET is among the most common neurological diseases with a prevalence (age > 40 years) estimated to be 4.0% and prevalence in advanced age (' 90 years) exceeding 20%. ET, often referred to as "familial tremor", is generally regarded as a highly genetic disorder with families with affecteds over multiple generations, and twin studies showing high concordance among monozygotic twins. Probands (affected with ET) and relatives were enrolled in a family study of ET at Columbia University, New York between 2011 - 2014. The study was approved by the Institutional Review Board at Columbia University and written informed consent was obtained from all enrollees. The criteria for enrollment were: 1) the proband had early-onset ET with age at onset < 50 years, 2) the proband had a diagnoses of definite or probable ET, 3) in addition to the proband there were at least two affected relatives in the family, 4) additional affected and unaffected family members were ... (Show More)

Archive Link Archive Accession
dbGaP phs000966

Who archives the data?

There are no publications available