Gene Expression in Postmortem DLPFC and Hippocampus from Schizophrenia and Mood Disorders
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Whole-genome expression analysis across nine major mental disorders with emphasis on schizophrenia (SZ), bipolar disorder (BP) and major depression (MDD) as compared to controls (C), allows examining disease-specific changes and potential common molecular pathogenic mechanisms. Three relevant regions were assessed: hippocampus (mRNA) and dorsolateral prefrontal cortex (mRNA), and in control tissue, dura (mRNA) as well as genotypes, for a large cohort of individuals. We found a pattern of downregulation of gene expression in SZ, differences in expression between SZ and BP, and between the regions. 37 genes were differentially expressed in SZ vs C in both DLPFC and Hippocampus.
Table 1: The number of subjects in each array and mental disorder.
|Genotyping (SNP Array)||2||3||... (Show More)|