Study

Gene Expression in Postmortem DLPFC and Hippocampus from Schizophrenia and Mood Disorders

Study ID Alternative Stable ID Type
phs000979 Case-Control

Study Description

Whole-genome expression analysis across nine major mental disorders with emphasis on schizophrenia (SZ), bipolar disorder (BP) and major depression (MDD) as compared to controls (C), allows examining disease-specific changes and potential common molecular pathogenic mechanisms. Three relevant regions were assessed: hippocampus (mRNA) and dorsolateral prefrontal cortex (mRNA), and in control tissue, dura (mRNA) as well as genotypes, for a large cohort of individuals. We found a pattern of downregulation of gene expression in SZ, differences in expression between SZ and BP, and between the regions. 37 genes were differentially expressed in SZ vs C in both DLPFC and Hippocampus.

Table 1: The number of subjects in each array and mental disorder.

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Anxiety Williams Tics Neuro Control Bipolar PTSD Autism MDD OCD ED Substance Schizo
Genotyping (SNP Array) 2 3
Anxiety Williams Tics Neuro Control Bipolar PTSD Autism MDD OCD ED Substance Schizo
Genotyping (SNP Array) 2 3 345 76 14 148 7 7 7 190
Hippocampus (mRNA) 1 3 281 51 7 88 5 1 6 134
Dura Mater (mRNA) 79 75
DLPFC (mRNA) 1 2 3 2 347 97 12 15 150 9 2 5 202

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Archive Link Archive Accession
dbGaP phs000979

Who archives the data?

There are no publications available