Identification of Putative Neoantigens in Stage III Melanoma

Study ID Alternative Stable ID Type
phs001005 Case Set

Study Description

This study of three metastatic melanoma patients utilized exome sequencing and RNA sequencing to help identify putative neoantigen peptides that could be further validated by standard immunological assays before design of a personalized vaccine. For each set of neoantigens identified and verified by standard assays, we designed GMP peptides that correspond to the top neoantigens, then used these to condition dendritic cell isolates from each patient. The conditioned dendritic cells were used as the vaccine in three rounds of vaccination, followed by monitoring for T cell memory response to each of the neoantigens.

Archive Link Archive Accession
dbGaP phs001005

Who archives the data?

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