Cincinnati Children's Hospital Medical Center (CCHMC) - eMERGE Phase IIIA Data
|Study ID||Alternative Stable ID||Type|
This submission includes genotyping or sequencing data from separate cohorts, each is described in separate paragraphs below.
Extreme early onset obesity
Obesity is a serious epidemic condition and on the rise in the United States. Today, nearly one out of three children is overweight or obese in this country. According to the Center for Disease Control, 35.7% of American adults and 17% of American children are obese. The medical costs associated with obesity are estimated to be in the billions. Without a doubt, interplay of additive genetic effects and common environmental effects influence this complex disease. However, despite being exposed to so-called "obesogenic environment", a large proportion of the population remains of normal weight. These observations suggest that innate, non-environmental, factors make some individuals more susceptible to obesity providing support for biological mechanisms, and thus genetic factors, to underlie the individual's response to the obesogenic environment. In young children with severe obesity the relative ... (Show More)