The Finland-United States Investigation of NIDDM Genetics (FUSION) Tissue Biopsy Study

Study ID Alternative Stable ID Type
phs001048 Cohort

Study Description

The Finland-United States Investigation of NIDDM Genetics (FUSION) study is a long-term effort to identify genetic variants that predispose to type 2 diabetes (T2D) or that impact the variability of T2D-related quantitative traits (QTs). Skeletal muscle and adipose are major insulin target tissues and play key roles in insulin resistance. We hypothesize that a subset of T2D and related QT variants alter gene expression in skeletal muscle and adipose tissue. For this FUSION Tissue Biopsy Study, we are obtaining and analyzing RNA-Seq, microRNA (miRNA)-Seq, DNA methylation (methyl)-Seq, and enhancer RNA (eRNA)-Seq data on biopsy samples from 331 individuals from across the range of glucose tolerance: 128 normal glucose tolerance (NGT), 84 impaired glucose tolerance (IGT), 52 impaired fasting glucose (IFG), and 67 newly-diagnosed T2Ds. Participants completed two study visits, two weeks apart. First visits were comprised of most of the clinical phenotyping, including four-point OGTT (fasting, and 30, 60, and 120 minute post-load); BMI, WHR; lipids; blood pressure; and many other ... (Show More)

Archive Link Archive Accession
dbGaP phs001048

Who archives the data?

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