Common Deleterious Germline Variants Shape the Urothelial Cancer Genome

Our study used whole-exome, whole-genome, and RNA sequencing to analyze samples from primary tumors, locally recurrent or metastatic urothelial tumors collected over time, and matched normal urothelium. We described the molecular landscape of mutational signatures and structural variants in chemotherapy-resistant urothelial cancer.

• Type: Case Set
• Archiver: The database of Genotypes and Phenotypes (dbGaP)