Integrated Genetic and Pharmacologic Interrogation of Rare Cancers

Study ID Alternative Stable ID Type
phs001121 Cohort

Study Description

Due to the paucity of patient derived models in rare cancers, identification of therapeutic targets remains challenging. We developed a patient derived model, CLF-PED-015-T, from a patient with an undifferentiated sarcoma. From this model, we performed pooled RNAi and CRISPR-Cas9 negative selection screens and integrated that with a small molecule screen. Integration of these data identified CDK4 and XPO1 as potential therapeutic targets.

Archive Link Archive Accession
dbGaP phs001121

Who archives the data?

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