Human Gene Expression Patterns Associated with Experimental P. falciparum Infection

Study ID Alternative Stable ID Type
phs001346 Clinical Trial

Study Description

Experimental exposure to malaria parasites can lead to development of protective immunity, providing a foothold for the development of a malaria vaccine. The goal of this study is to investigate immune transcriptional profiles associated with malaria protective immune responses induced by experimental Chemo-Prophylaxis and Sporozoites (CPS) immunization of P. falciparum-naive human volunteers. Samples for this study were obtained from a CPS-immunization study conducted in 2011 ( Identifier: NCT01218893), where healthy volunteers received CPS-immunization with bites from different numbers of P. falciparum-infected mosquitoes (three times 15 (n=5), 10 (n=9) or 5 (n=10)). Five control subjects received uninfected mosquito bites under chloroquine prophylaxis. Fifteen weeks after discontinuation of chloroquine prophylaxis, all volunteers were challenged by exposure to infected mosquito bites.

Study Design:
A maximum of 30 volunteers were divided into four groups. All volunteers received weekly chloroquine prophylaxis for ... (Show More)

Archive Link Archive Accession
dbGaP phs001346

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