NCI Cancer Model Development for the Human Cancer Model Initiative (HCMI)
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The Cancer Model Development Center (CMDC) project is part of the Human Cancer Model Initiative (HCMI) and is managed by the Office of Cancer Genomics (OCG) within the Center for Cancer Genomics (CCG). The goal of the HCMI is to generate novel human tumor-derived models, which are annotated with genomic and clinical data. The CMDCs are tasked by the NCI with producing a proportion of the next-generation cancer models (Cancer Model Development Centers). Models developed by the CMDCs are being derived from a number of tumor types and subtypes, including rare and understudied cancers. The number of models and the clinical sites from which patient samples will be acquired will be increasing; for specifics, visit the HCMI web site (URL listed above).
The cancer models developed by the CMDCs will be associated with clinical and genomic data and will aim to more faithfully recapitulate the cellular complexity and heterogeneity of human tumors; ... (Show More)