Neoantigen Landscape in a Hypermutated Glioblastoma Arising in a Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy

Whole genome and exome-based DNA sequencing of germline and tumor specimens from serial samples of patients with glioblastoma. The data set includes several metastases and recurrences from a patient with germline POLE-deficiency. The data reveal extensive tumor heterogeneity, clonal evolution, and genomic responses to immunotherapy.

• Type: Longitudinal
• Archiver: The database of Genotypes and Phenotypes (dbGaP)