Genomics of Pediatric Renal Medullary Carcinomas

Study ID Alternative Stable ID Type
phs001800 Cohort

Study Description

We derived faithful cancer cell lines from patients with a diagnosis of renal medullary carcinomas (RMC). These models have been sequenced with whole genome, exome and transcriptome technologies along with the patient's primary germline and tumor samples. We took these faithful models and performed loss-of-function genetic perturbation screens (e.g. RNAi and CRISPR-Cas9) along with an orthogonal small molecule screen. We identified the ubiquitin-proteasome system as an important target in RMC as well as other SMARCB1 deficient cancers.

Archive Link Archive Accession
dbGaP phs001800

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