CRISPR-Mediated ASD Gene Knockout Reduces Neuronal Activity

Study ID Alternative Stable ID Type
phs001816 Case-Control

Study Description

Autism Spectrum Disorder is phenotypically and genetically heterogeneous. We present a CRISPR gene editing strategy to insert a protein tag and premature termination sites creating an induced pluripotent stem cell (iPSC) knockout resource for functional studies of 10 ASD-relevant genes (AFF2/FMR2, ANOS1, ASTN2, ATRX, CACNA1C, CHD8, DLGAP2, KCNQ2, SCN2A, TENM1). Neurogenin 2 (NGN2)-directed induction of iPSCs allowed production of excitatory ... (Show More)

Archive Link Archive Accession
dbGaP phs001816

Who archives the data?

There are no publications available