NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III - Red Blood Cell Omics (RBC-Omics) Study
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The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) is an initiative launched by the National Heart, Lung, and Blood Institute (NHLBI) with the goal to improve transfusion medicine practice, ensure safety and reduce risks.
Extensive variation exists in donor iron metabolism, hemoglobin production, and hemolysis. Despite this variation, current blood banking guidelines regulating blood donation frequency, donation volume, and storage time and conditions remain uniform for all donors. The RBC-Omics study proposed to investigate if this approach is appropriate. Specifically, the RBC-Omics study:
- Established a multi-ethnic cohort of blood donors with well-characterized demographic, behavioral, and donation history.
- Developed a database linking donations from these blood donors to outcomes in transfusion recipients.
- Identify genetic factors impacting hemoglobin, donation history, ferritin, and iron metabolism.
- Identify markers and clinical factors associated with the iron-related disorders pica and restless leg syndrome ... (Show More)