Genetic neuroscience: how human genes and alleles shape neuronal phenotypes
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The goal of our collaborative, interdisciplinary effort is to develop powerful, generalizable approaches for discovering how risk variants for psychiatric disorders shape neurobiological processes at multiple levels of analysis, and to identify the processes whose dysregulation underlies disease. To do this, we propose to develop new experimental and inferential systems to bridge a longstanding gap between human genetics and experimental biology.
Induced pluripotent stem cells (iPSCs) are being widely adopted for disease modeling and cellular genetic studies. The largest publicly available collection of iPSCS has been generated from 2,500 donors by the California Institute for Regenerative Medicine. We wish to share genetic-variation data we have generated for the CIRM iPSC donors. These data can be used to identify (for experiments) lines with specific genotypes of interest and lines from donors with high or low polygenic risk scores for phenotypes of interest. The data can also be used to identify acquired mutations in the iPSC lines.